Biosoluble microneedles (BM) are miniature needles made of biocompatible and soluble materials (e.g. hyaluronic acid, polysaccharides, polylactide, etc.). Biosoluble microneedles are an innovative platform for painless administration of vaccines and drugs through the skin. This increases the bioavailability of drugs and improves patient compliance. They are used for transdermal (through the skin) administration of drugs and vaccines without the pain and discomfort associated with traditional injections.
How do biosoluble microneedles work?
- Application to the skin: The microneedle plate is pressed against the skin.
- Penetration: The microneedles penetrate the stratum corneum of the epidermis, but do not reach the pain receptors, making the procedure painless.
- Dissolution: The needles dissolve in the skin layers, releasing the active substance.
- Absorption: The drug penetrates the bloodstream or lymphatic system, providing a therapeutic effect.
Advantages of biosoluble microneedles
- Painlessness – do not reach pain receptors.
- Ease of use – can be used without medical personnel.
- No medical waste – dissolves completely, no needle disposal.
- Increased drug stability – do not require a cold chain of storage.
- Effective drug delivery – the possibility of controlled release of active substances.
Application areas
- Vaccination (flu, COVID-19, measles, HPV, etc.).
- Insulin delivery for diabetics.
- Local administration of analgesics and anti-inflammatory drugs.
- Cosmetology (anti-aging and moisturizing products, collagen stimulation).
Development prospects
Clinical trials of new drugs are underway, the possibility of delivering DNA and RNA vaccines, biologically active substances and even stem cells are being studied. This technology can revolutionize medicine, making vaccination and drug therapy more accessible, more effective and less painful.
