The University of Michigan is creating an ovarian cell atlas that could lead to the development of artificial ovaries for women with premature menopause or cancer-related diseases.
Scientists at the University of Michigan have created a detailed atlas of ovarian cells – a map of the types of cells present in the ovaries, how they interact with each other, and how they change with age or disease.
Why is this necessary?
- Many women face premature menopause or loss of ovarian function due to cancer treatments (such as chemotherapy or radiation therapy).
- Loss of ovarian function leads not only to infertility, but also to serious hormonal problems – osteoporosis, cardiovascular disease, and a decrease in quality of life.
What’s new?
- Using modern single-cell transcriptomics (single-cell RNA-seq), they have compiled a detailed map of gene expression in ovarian cells.
- This has made it possible to understand which cells play a key role in the maturation of eggs, the synthesis of hormones and the maintenance of reproductive function.
What will this lead to?
- The development of artificial ovaries – bioengineered structures that can replace lost functions.
- Targeted therapy for female infertility and early menopause.
- Personalized medicine – the ability to predict reproductive potential and correct hormonal imbalances.
In principle, we are talking about creating a “living prosthesis” that will in the future provide women with not only the ability to bear children, but also maintain normal hormonal balance.
